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June 1, 1933The Journal of Immunology

Experimental Study of an Antipoliomyelitic Serum from Monkeys Artificially Immunized with an Organism Cultivated from Poliomyelitis Nervous Tissue

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Key result

Subcutaneous injections of an organism cultivated from poliomyelitis virus filtrates immunized Macacus rhesus monkeys, producing serums that neutralized the virus in vitro.

Population

Macacus rhesus monkeys

Design

Preclinical

Authors

FEFrederick EbersonUniversity of MinnesotaWMW. G. MossmanUniversity of California, San Francisco

Discussion

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Implication

Animal immunization yields neutralizing antibodies; leaves open translation to human poliomyelitis prevention.

Structured PICO

P
Population
Macacus rhesus monkeys experimentally immunized against poliomyelitis virus using subcutaneous injections of a cultivated organism.
I
Intervention
Subcutaneous injections of an organism cultivated from Berkefeld N filtrates of poliomyelitis virus (twenty-fourth subplant)
O
Outcome
Neutralizing power of serums for poliomyelitis virus and resistance to intracerebral inoculationsurrogate

Immunization of monkeys with cultivated poliomyelitis virus organisms produced neutralizing serums and conferred resistance to intracerebral infection.

Cite This Study

Eberson et al. (1933) studied Poliomyelitis. Subcutaneous injections of an organism cultivated from Berkefeld N filtrates of poliomyelitis virus was evaluated on Neutralizing power of serums for poliomyelitis virus and resistance to intracerebral inoculation. Subcutaneous injections of an organism cultivated from poliomyelitis virus filtrates immunized Macacus rhesus monkeys, producing serums that neutralized the virus in vitro.

synapsesocial.com/papers/6a9f8787cd2174b401b20b35https://doi.org/10.4049/jimmunol.24.6.433
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SURVIVAL AND MULTIPLICATION OF THE VIRUS OF POLIOMYELITIS IN VITRO1930 · 13 citations
  2. 2CONCERNING SURVIVAL AND VIRULENCE OF THE MICROORGANISM CULTIVATED FROM POLIOMYELITIC TISSUES1915 · 11 citations
  3. 3OBSERVATIONS ON IMMUNITY OF MONKEYS TO EXPERIMENTAL POLIOMYELITIS1917 · 6 citations
  4. 4Evidence of Possible Occurrence of Anaphylactic Phenomena in Poliomyelitis Immune Monkeys.1932 · 1 citations
  5. 5Experimental Immunization in Poliomyelitis1927 · 23 citations