Key result
Formalized poliomyelitis virus produced active tissue and humoral immunity in monkeys, with a 5-cc dose providing optimal resistance comparable to active virus.
Why the study?
Does formalized poliomyelitis virus produce active immunity in monkeys compared to active or phenolized virus?
Does formalized poliomyelitis virus produce active immunity in monkeys compared to active or phenolized virus?
Formalized poliomyelitis virus is an effective antigen for producing active immunity in monkeys, with 5 cc being the optimal dose.
Authors
No takes yet. Share an insight, caveat, or question.
Supports inactivated polio antigen testing in primate models; leaves open human translation and safety.
Maurice Brodie (1934) studied Poliomyelitis (n=26). Formalized poliomyelitis virus vs. Active virus was evaluated on Tissue and humoral immunity. Formalized poliomyelitis virus produced active tissue and humoral immunity in monkeys, with a 5-cc dose providing optimal resistance comparable to active virus.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: