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August 1, 1936The Journal of Immunology

Antibody in Relation to Immunity in Acute Poliomyelitis

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Population

Monkeys and human beings with or at risk of acute poliomyelitis

Design

Review

Authors

JKJohn A. KolmerUniversity of the SciencesARAnna M. RuleUniversity of Rochester

Discussion

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Implication

Monkey immunization data link antibodies to protection; hypothesis-generating for human poliomyelitis vaccines, with clinical translation unproven.

Structured PICO

P
Population
Monkeys and human beings with or at risk of acute poliomyelitis
I
Intervention
Poliomyelitis antibody or immunization with living virus (active, glycerinated, and ricinoleated)
O
Outcome
Presence of antibody in blood and protection against intracerebral injection of virulent virussurrogate

Antibodies against poliomyelitis virus are produced following infection or vaccination and appear to contribute to immunity, though clinical efficacy in humans remains uncertain.

Cite This Study

Kolmer et al. (1936) studied this question.

synapsesocial.com/papers/6a968ea13765f840908985ffhttps://doi.org/10.4049/jimmunol.31.2.119
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tests for Immunity to Acute Anterior Poliomyelitis1935 · 4 citations
  2. 2On the Property of Certain Normal Animal Sera to Neutralize the Virus of Poliomyelitis.1932 · 6 citations
  3. 3Experimental Immunization in Poliomyelitis1927 · 23 citations
  4. 4Experimental Study of an Antipoliomyelitic Serum from Monkeys Artificially Immunized with an Organism Cultivated from Poliomyelitis Nervous Tissue1933 · 2 citations
  5. 5Serum Neutralizing Antibodies to the Infecting Strain of Virus in Poliomyelitis Patients.1948 · 22 citations