January 1, 1931The Journal of Experimental MedicineOpen Access

Immunity Following the Injection of Monkeys With Mixtures of Poliomyelitis Virus and Convalescent Human Serum

Q: What is the clinical evidence from this study?

Study design: Other. Population: Poliomyelitis. Intervention: Poliomyelitis virus neutralized by convalescent human serum. Primary outcome: Protection against experimental disease and pathogenic effect.

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Key result

Injection of monkeys with poliomyelitis virus neutralized by convalescent human serum conferred protection against the disease without causing pathogenic effects.

Authors

CRC. P. RhoadsGrinnell College

Discussion

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Implication

Provides proof-of-concept for neutralized-virus protection in primates; leaves open translation to human poliomyelitis prevention.

PICO

Population

Monkeys treated with poliomyelitis virus neutralized by specific antiserum to induce active immunity.

Intervention / Comparator

Poliomyelitis virus neutralized by convalescent human serum

Primary Outcome

Protection against experimental disease and pathogenic effect

Cite This Study

C. P. Rhoads (1931) studied Poliomyelitis. Poliomyelitis virus neutralized by convalescent human serum was evaluated on Protection against experimental disease and pathogenic effect. Injection of monkeys with poliomyelitis virus neutralized by convalescent human serum conferred protection against the disease without causing pathogenic effects.

synapsesocial.com/papers/6a92b1bf030f5598b797a25b https://doi.org/10.1084/jem.53.1.115

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Immunity Following the Injection of Monkeys With Mixtures of Poliomyelitis Virus and Convalescent Human Serum

Discussion

Member takes

Implication

PICO

Cite This Study

Immunity Following the Injection of Monkeys With Mixtures of Poliomyelitis Virus and Convalescent Human Serum

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider