What question did this study set out to answer?

To determine whether inoculations that do not induce clinical paralysis can confer protective immunity against experimental poliomyelitis in monkeys.

January 27, 1917JAMA

Observations on Immunity of Monkeys to Experimental Poliomyelitis

Q: What is the clinical evidence from this study?

Study design: Other. Population: Experimental poliomyelitis (n=3). Intervention: Inoculations not followed by obvious evidence of infection. Primary outcome: Immunity to subsequent injection with virulent virus.

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Key result

Inoculations not followed by obvious evidence of infection appeared to confer immunity to experimental poliomyelitis in three monkeys.

Authors

EREdward C. RosenowCalifornia Institute of Technology

Discussion

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Implication

Does not support clinical use; leaves open whether infection-free inoculations prevent human poliomyelitis.

Key Points

To determine whether inoculations that do not induce clinical paralysis can confer protective immunity against experimental poliomyelitis in monkeys.
Assessed resistance to virulent virus challenge in three monkeys (N=3) that showed no evidence of infection after prior inoculations.
Administered distinct primary exposures to each monkey: an intracerebral injection of pleomorphic streptococci culture, a central nervous system emulsion from streptococcus-paralyzed animals, or standard virus inoculation.
All three monkeys successfully exhibited immunity to subsequent virulent poliovirus challenge despite lacking prior paralytic symptoms or overt evidence of infection.

PICO

Population

Three monkeys subjected to experimental poliomyelitis inoculations without obvious evidence of infection.

Intervention / Comparator

Inoculations not followed by obvious evidence of infection

Primary Outcome

Immunity to subsequent injection with virulent virus

Cite This Study

Edward C. Rosenow (1917) studied Experimental poliomyelitis (n=3). Inoculations not followed by obvious evidence of infection was evaluated on Immunity to subsequent injection with virulent virus. Inoculations not followed by obvious evidence of infection appeared to confer immunity to experimental poliomyelitis in three monkeys.

synapsesocial.com/papers/6a9ebe6a37e106657b192aef https://doi.org/10.1001/jama.1917.04270010280012

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Observations on Immunity of Monkeys to Experimental Poliomyelitis

Discussion

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Implication

Key Points

PICO

Cite This Study

Observations on Immunity of Monkeys to Experimental Poliomyelitis

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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