Key result
Repeated subcutaneous injections of crude unmodified virus immunized monkeys against poliomyelitis, allowing them to resist twenty to forty fatal doses of potent virus.
Why the study?
Does vaccination with crude unmodified virus protect monkeys against experimental poliomyelitis?
Does vaccination with crude unmodified virus protect monkeys against experimental poliomyelitis?
Early experimental models showed that monkeys could be immunized against poliomyelitis using crude virus, though the method carried a risk of vaccine-induced disease.
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Animal immunization with crude virus protects monkeys; leaves open safe human vaccine translation for poliomyelitis.
Harold Abramson (1918) studied Poliomyelitis. Crude unmodified virus was evaluated on Resistance to fatal doses of potent virus. Repeated subcutaneous injections of crude unmodified virus immunized monkeys against poliomyelitis, allowing them to resist twenty to forty fatal doses of potent virus.
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