Key result
Early 1935 polio immunization trials using inactivated monkey cord virus prove unsatisfactory and halt quickly.
Population
Children inoculated with suspensions of infected monkey cord in 1935
Design
Review
Authors
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Warns against unmonitored mass immunization during outbreaks; leaves open how modern assays and serotype awareness transformed vaccine development.
This historical review highlights the challenges and unsatisfactory results of early (1935) attempts at poliomyelitis vaccination.
John R. Paul (1954) conducted a review in Poliomyelitis. Artificial immunization was evaluated. Early 1935 trials of artificial immunization against poliomyelitis using inactivated monkey cord virus in several thousand children were unsatisfactory and quickly terminated.
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