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January 1, 1932Experimental Biology and Medicine

Evidence of Possible Occurrence of Anaphylactic Phenomena in Poliomyelitis Immune Monkeys.

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Population

Monkeys immune to poliomyelitis, n=3 in the first group.

Design

Preclinical

Follow-up

47 days or more after immunization

Authors

WBW. B. BrebnerUniversity of Oxford

Discussion

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Implication

May signal route-specific anaphylaxis risk in immune animal models; hypothesis-generating and should not yet inform human polio vaccination or therapy.

Structured PICO

P
Population
Monkeys immune to poliomyelitis (convalescent from experimental infection, experimentally immunized, or naturally immune), n=3 in the first group.
I
Intervention
Intrasplenic or intraperitoneal injection of poliomyelitis virus.
O
Outcome
Death (sudden or lingering) and anaphylactic reaction symptoms.safety

Intrasplenic or intraperitoneal injection of poliomyelitis virus in immune monkeys causes fatal anaphylactic reactions.

Cite This Study

W. B. Brebner (1932) studied this question.

synapsesocial.com/papers/6a95c8e2e844cd4f5c48f86ehttps://doi.org/10.3181/00379727-29-5881
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1OBSERVATIONS ON IMMUNITY OF MONKEYS TO EXPERIMENTAL POLIOMYELITIS1917 · 6 citations
  2. 2Experimental Study of an Antipoliomyelitic Serum from Monkeys Artificially Immunized with an Organism Cultivated from Poliomyelitis Nervous Tissue1933 · 2 citations
  3. 3Antibody Response in Monkeys Following Oral Administration of Poliomyelitis Virus1948 · 14 citations
  4. 4EXPERIMENTAL POLIOMYELITIS IN MONKEYS1910 · 61 citations
  5. 5AN ACCELERATED FEBRILE REACTION IN MONKEYS UPON REINOCULATION WITH POLIOMYELITIS VIRUS1931 · 4 citations