Key result
Sequential exposure of Cynomolgus monkeys to poliomyelitis virus via various alimentary and respiratory routes demonstrated varying rates of paralytic infection and histological lesions.
Population
26 Cynomolgus monkeys
Design
Preclinical
Authors
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Suggests route-specific polio susceptibility in primates; leaves open human transmission pathways and prevention implications.
In cynomolgus monkeys, poliomyelitis virus entry and subsequent infection appear more likely through the oropharynx and respiratory routes than through the lower gastrointestinal tract.
Faber et al. (1943) studied Poliomyelitis (n=26). Poliomyelitis virus exposure via various routes was evaluated on Clinical evidence of poliomyelitic infection or paralytic poliomyelitis. Sequential exposure of Cynomolgus monkeys to poliomyelitis virus via various alimentary and respiratory routes demonstrated varying rates of paralytic infection and histological lesions.
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