Key result
Oropharyngeal exposure to poliomyelitis virus in cynomolgus monkeys resulted in early infection of the ganglia supplying the exposed mucous membranes, peaking on the 5th day, prior to CNS involvement.
Population
Cynomolgus monkeys
Comparison
Simple oropharyngeal exposure to poliomyelitis… vs Control animals permitted to survive
Design
Preclinical
Follow-up
Up to 30 days
Authors
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Peripheral ganglia may represent early polio entry sites in primates; leaves open translation to human pathogenesis or prevention.
Poliomyelitis virus infects peripheral ganglia supplying the exposed mucous membranes prior to CNS involvement following oropharyngeal exposure in monkeys.
Faber et al. (1951) studied Poliomyelitis. Simple oropharyngeal exposure to poliomyelitis virus vs. Control animals was evaluated on Histological signs of infection and virus detection in ganglia and CNS. Oropharyngeal exposure to poliomyelitis virus in cynomolgus monkeys resulted in early infection of the ganglia supplying the exposed mucous membranes, peaking on the 5th day, prior to CNS involvement.
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