What question did this study set out to answer?

To investigate whether asymptomatic monkeys housed in a poliomyelitis research environment develop neurotropic lesions across specific peripheral ganglia, characterizing potential pathways of infection entry and egress.

April 1, 1950The Journal of Experimental MedicineOpen Access

Studies on the Entry and Egress of Poliomyelitic Infection

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Poliomyelitic infection (n=26). Intervention: Housing in a poliomyelitis research laboratory without isolation precautions vs. Newly arrived monkeys (1 to 3 days after arrival). Primary outcome: Neuronophagia in peripheral ganglia.

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Key result

Housing asymptomatic monkeys in a poliomyelitis research laboratory without isolation precautions resulted in neuronophagia in 65% of animals compared to 0% in newly arrived monkeys.

Population

26 rhesus and cynomolgus monkeys without signs or symptoms of poliomyelitis

Comparison

Housing in a poliomyelitis research laboratory… vs Sacrifice 1 to 3 days after arrival

Design

Preclinical

Follow-up

17 days to 10.5 months

Authors

HFHarold K. FaberPenn Presbyterian Medical Center RSRosalie J. SilverbergNational Institutes of Health LDLuther DongUniversity of California, San Francisco

Discussion

Member takes

Implication

May inform isolation in neurotropic virus labs; leaves open translation to human subclinical poliomyelitis.

Key Points

To investigate whether asymptomatic monkeys housed in a poliomyelitis research environment develop neurotropic lesions across specific peripheral ganglia, characterizing potential pathways of infection entry and egress.
Histologically examined peripheral ganglia (gasserian, nodose, superior cervical sympathetic, celiac, and cranial nerves VII/IX) in 26 symptom-free rhesus and cynomolgus monkeys.
Compared 9 newly arrived animals sacrificed 1 to 3 days after arrival against 17 animals housed without special isolation precautions for 17 days to 10.5 months.
Neuronophagia was present in 65% of exposed animals compared with 0% of newly arrived controls, accompanied by a higher burden of infiltrative lesions.
Pathology concentrated most heavily in the gasserian and superior cervical sympathetic ganglia, occurred less frequently in nodose and celiac ganglia, and was absent in cranial nerves VII and IX.
Lesion morphology and distribution supported a centripetal route of viral spread, mimicking subclinical poliomyelitic infection in humans.

Study Design

Type

Observational (n=26)

Structured PICO

Population

26 asymptomatic rhesus and cynomolgus monkeys, comprising 9 newly arrived and 17 housed in a poliomyelitis research lab for up to 10.5 months.

Exposure

Housing in a poliomyelitis research laboratory without special isolation precautions for 17 days to 10.5 months ('old' animals)

Comparator

Sacrifice 1 to 3 days after arrival ('new' animals)

Outcome

Incidence, numbers, size, and character of lesions in peripheral ganglia (gasserian, nodose, superior cervical sympathetic, and celiac)surrogate

Main Result

Absolute Event Rate: 65% vs 0%

Asymptomatic acquisition of neurotropic lesions in casually exposed monkeys suggests a model for subclinical poliomyelitis in humans.

Limitations

Lesions were not positively identified as poliomyelitic
Lesions not positively identified as poliomyelitic

Cite This Study

Faber et al. (1950) conducted an observational in Poliomyelitic infection (n=26). Housing in a poliomyelitis research laboratory without isolation precautions vs. Newly arrived monkeys (1 to 3 days after arrival) was evaluated on Neuronophagia in peripheral ganglia. Housing asymptomatic monkeys in a poliomyelitis research laboratory without isolation precautions resulted in neuronophagia in 65% of animals compared to 0% in newly arrived monkeys.

synapsesocial.com/papers/6a99487a2a30e7e4c5bd4d68 https://doi.org/10.1084/jem.91.4.417

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April 1, 1950The Journal of Experimental MedicineOpen Access

Studies on the Entry and Egress of Poliomyelitic Infection

View Full Paper

Ask AI

Bookmark

Key result

Housing asymptomatic monkeys in a poliomyelitis research laboratory without isolation precautions resulted in neuronophagia in 65% of animals compared to 0% in newly arrived monkeys.

Population

26 rhesus and cynomolgus monkeys without signs or symptoms of poliomyelitis

Comparison

Housing in a poliomyelitis research laboratory… vs Sacrifice 1 to 3 days after arrival

Design

Preclinical

Follow-up

17 days to 10.5 months

Authors

HFHarold K. FaberPenn Presbyterian Medical Center RSRosalie J. SilverbergNational Institutes of Health LDLuther DongUniversity of California, San Francisco

Discussion

Member takes

Implication

May inform isolation in neurotropic virus labs; leaves open translation to human subclinical poliomyelitis.

Key Points

To investigate whether asymptomatic monkeys housed in a poliomyelitis research environment develop neurotropic lesions across specific peripheral ganglia, characterizing potential pathways of infection entry and egress.
Histologically examined peripheral ganglia (gasserian, nodose, superior cervical sympathetic, celiac, and cranial nerves VII/IX) in 26 symptom-free rhesus and cynomolgus monkeys.
Compared 9 newly arrived animals sacrificed 1 to 3 days after arrival against 17 animals housed without special isolation precautions for 17 days to 10.5 months.
Neuronophagia was present in 65% of exposed animals compared with 0% of newly arrived controls, accompanied by a higher burden of infiltrative lesions.
Pathology concentrated most heavily in the gasserian and superior cervical sympathetic ganglia, occurred less frequently in nodose and celiac ganglia, and was absent in cranial nerves VII and IX.
Lesion morphology and distribution supported a centripetal route of viral spread, mimicking subclinical poliomyelitic infection in humans.

Study Design

Type

Observational (n=26)

Structured PICO

Population

26 asymptomatic rhesus and cynomolgus monkeys, comprising 9 newly arrived and 17 housed in a poliomyelitis research lab for up to 10.5 months.

Exposure

Housing in a poliomyelitis research laboratory without special isolation precautions for 17 days to 10.5 months ('old' animals)

Comparator

Sacrifice 1 to 3 days after arrival ('new' animals)

Outcome

Incidence, numbers, size, and character of lesions in peripheral ganglia (gasserian, nodose, superior cervical sympathetic, and celiac)surrogate

Main Result

Absolute Event Rate: 65% vs 0%

Asymptomatic acquisition of neurotropic lesions in casually exposed monkeys suggests a model for subclinical poliomyelitis in humans.

Limitations

Lesions were not positively identified as poliomyelitic
Lesions not positively identified as poliomyelitic

Cite This Study

synapsesocial.com/papers/6a99487a2a30e7e4c5bd4d68 https://doi.org/10.1084/jem.91.4.417

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