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March 1, 1947The Journal of Experimental MedicineOpen Access

The Significance of Lesions in Peripheral Ganglia in Chimpanzee and in Human Poliomyelitis

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Population

18 inoculated chimpanzees, 13 uninoculated control chimpanzees, and 18 fatal human poliomyelitis cases

Comparison

Poliomyelitis virus inoculation or natural… vs Uninoculated control chimpanzees

Design

Preclinical

Authors

DBDavid BodianUniversity of Maryland, BaltimoreHHHoward A. HoweOklahoma State Department of Health

Discussion

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Implication

Suggests CNS origin of sensory lesions in poliomyelitis; leaves open primary peripheral infection in other neurotropic viruses.

Structured PICO

P
Population
18 inoculated chimpanzees, 13 uninoculated control chimpanzees, and 18 fatal human poliomyelitis cases
I
Intervention
Poliomyelitis virus inoculation (in chimpanzees) or natural infection (in humans)
C
Comparator
Uninoculated control chimpanzees
O
Outcome
Histopathological evidence of lesions in peripheral ganglia to determine the route of transmission of virus from the alimentary tract to the CNSsurrogate

Histopathological analysis of peripheral ganglia in poliomyelitis suggests that sensory ganglia lesions likely result from centrifugal spread of the virus from the CNS rather than primary peripheral infection.

Limitations

  • Specificity of lesions in sympathetic ganglia has not been established beyond doubt as being due to poliomyelitis
  • Presence of characteristic lesions in sensory ganglia cannot reveal whether the virus reached the ganglia from the periphery or from the central nervous system

Cite This Study

Bodian et al. (1947) studied this question.

synapsesocial.com/papers/6a968e623765f840908985d8https://doi.org/10.1084/jem.85.3.231
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1A NEUROPATHOLOGICAL STUDY OF ACUTE HUMAN POLIO-MYELITIS WITH SPECIAL REFERENCE TO THE INITIAL LESION AND TO VARIOUS POTENTIAL PORTALS OF ENTRY1946 · 35 citations