What is the clinical evidence from this study?

Study design: Observational. Population: Acute poliomyelitis (n=8). Intervention: Poliovirus infection. Primary outcome: Distribution of lesions consistent with viral entry through superficial nerve fibers.

April 1, 1946The Journal of Experimental MedicineOpen Access

A Neuropathological Study of Acute Human Polio-Myelitis With Special Reference to the Initial Lesion and to Various Potential Portals of Entry

View Full Paper

Ask AI

Bookmark

Key result

Histological examination of 8 fatal poliomyelitis cases suggested the virus primarily enters through the upper alimentary and respiratory tracts, with primary lesions in peripheral ganglia.

Population

8 patients dying of acute poliomyelitis

Design

Case_series

Authors

HFHarold K. FaberPenn Presbyterian Medical Center RSRosalie J. SilverbergNational Institutes of Health

Discussion

Member takes

Implication

Suggests pharyngeal entry in poliomyelitis; leaves open validation in larger modern cohorts before clinical application.

Study Design

Type

Observational (n=8)

Structured PICO

Population

8 patients dying of acute poliomyelitis whose peripheral and central nervous tissues were examined histologically.

Exposure

Histological examination of peripheral and central nervous tissues

Outcome

Distribution of lesions to determine portals of entry of the virus

The study suggests that the primary lesion of poliomyelitis occurs in the peripheral ganglia, with the pharynx being an especially favorable site for primary penetration.

Cite This Study

Faber et al. (1946) conducted an observational in Acute poliomyelitis (n=8). Poliovirus infection was evaluated on Distribution of lesions consistent with viral entry through superficial nerve fibers. Histological examination of 8 fatal poliomyelitis cases suggested the virus primarily enters through the upper alimentary and respiratory tracts, with primary lesions in peripheral ganglia.

synapsesocial.com/papers/6a99487a2a30e7e4c5bd4d69 https://doi.org/10.1084/jem.83.4.329

View Full Paper

Ask AI

Bookmark

April 1, 1946The Journal of Experimental MedicineOpen Access

A Neuropathological Study of Acute Human Polio-Myelitis With Special Reference to the Initial Lesion and to Various Potential Portals of Entry

View Full Paper

Ask AI

Bookmark

Key result

Histological examination of 8 fatal poliomyelitis cases suggested the virus primarily enters through the upper alimentary and respiratory tracts, with primary lesions in peripheral ganglia.

Population

8 patients dying of acute poliomyelitis

Design

Case_series

Authors

HFHarold K. FaberPenn Presbyterian Medical Center RSRosalie J. SilverbergNational Institutes of Health

Discussion

Member takes

Implication

Suggests pharyngeal entry in poliomyelitis; leaves open validation in larger modern cohorts before clinical application.

Study Design

Type

Observational (n=8)

Structured PICO

Population

8 patients dying of acute poliomyelitis whose peripheral and central nervous tissues were examined histologically.

Exposure

Histological examination of peripheral and central nervous tissues

Outcome

Distribution of lesions to determine portals of entry of the virus

The study suggests that the primary lesion of poliomyelitis occurs in the peripheral ganglia, with the pharynx being an especially favorable site for primary penetration.

Cite This Study

synapsesocial.com/papers/6a99487a2a30e7e4c5bd4d69 https://doi.org/10.1084/jem.83.4.329

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

1Essays on the Applied Physiology of the Nose.1941 · 192 citations

View Full Paper

Ask AI

Bookmark