May 1, 1950The Journal of Experimental MedicineOpen Access

Studies on Entry and Egress of Poliomyelitis Infection

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Population

Experimental model exposed to poliomyelitis virus

Design

Preclinical

Authors

HFHarold K. FaberPenn Presbyterian Medical Center RSRosalie J. SilverbergNational Institutes of Health LDLuther DongUniversity of California, San Francisco

Discussion

Member takes

Implication

Supports centripetal neural invasion in polio models; leaves open translation to human pathogenesis or therapy.

Structured PICO

Population

Experimental model exposed to poliomyelitis virus

Intervention

Direct exposure to poliomyelitis virus of the central end of a cut branch of the V cranial nerve or traumatized muscle of peripheral fibers of the VII motor nerve

Outcome

Spread of infection to the central nervous system (detected histologically and by subinoculation)surrogate

Experimental exposure of cranial nerves to poliomyelitis virus demonstrates centripetal spread to the CNS, paralleling the evolution of human disease.

Cite This Study

Faber et al. (1950) studied this question.

synapsesocial.com/papers/6a968e623765f840908985d6 https://doi.org/10.1084/jem.91.5.549

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Studies on Entry and Egress of Poliomyelitis Infection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Studies on Entry and Egress of Poliomyelitis Infection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider