Why the study?
Does oral ingestion of poliomyelitis virus lead to early infection of peripheral ganglia and viremia in cynomolgus monkeys?
Population
Cynomolgus monkeys (n=11)
Design
Preclinical
Follow-up
Up to 6 days
Authors
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Suggests early ganglionic involvement after oral polio exposure in primates; leaves open translation to human pathogenesis and prevention.
Does oral ingestion of poliomyelitis virus lead to early infection of peripheral ganglia and viremia in cynomolgus monkeys?
Oral ingestion of poliomyelitis virus in monkeys leads to early infection of peripheral ganglia, which likely serves as the source of contemporaneous viremia prior to CNS invasion.
Faber et al. (1953) studied this question.
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