January 1, 1967Japanese Journal of Medical Science and BiologyOpen Access

Immunofluorescent Study on the Pathogenesis of Oral Infection of Poliovirus in Monkey

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Population

31 monkeys with no detectable serum antibody against poliovirus.

Design

Preclinical

Follow-up

Up to 2 months for Japanese monkeys; up to 5 days or after…

Authors

MKMasatsugu KanamitsuSapporo Medical University AKAkiko KasamakiSapporo Medical University MOMIKIO OGAWAWalter and Eliza Hall Institute of Medical Research

Discussion

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Implication

Early mucosal replication sites in this model warrant further study; leaves open translation to human polio pathogenesis and vaccination.

Structured PICO

Population

31 monkeys (4 Japanese monkeys [Macaca fuscata] and 27 cynomolgus monkeys [Macaca irus] weighing 1.5 to 3.3 kg) with no detectable serum antibody against poliovirus.

Intervention

Oral or anal administration of type 1 poliovirus (virulent Mahoney strain or attenuated LSc, 2ab strain).

Outcome

Site of initial multiplication of the virus in the alimentary tract and distribution of virus in body tissues, investigated immunofluorescently and by virus isolation.surrogate

This preclinical study demonstrates that orally administered poliovirus initially multiplies in the oropharynx and intestinal reticulo-endothelial cells before causing viremia and central nervous system invasion.

Cite This Study

Kanamitsu et al. (1967) studied this question.

synapsesocial.com/papers/6a904164fdaee66aea8407d8 https://doi.org/10.7883/yoken1952.20.175

View Full Paper

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Immunofluorescent Study on the Pathogenesis of Oral Infection of Poliovirus in Monkey

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Immunofluorescent Study on the Pathogenesis of Oral Infection of Poliovirus in Monkey

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider