Population
Macacus rhesus monkey (n=1)
Design
Preclinical
Follow-up
48 hours
Authors
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Animal model of intranasal poliovirus exposure may clarify CNS entry routes; leaves open applicability to human disease.
The study describes an experimental model to determine the route of poliomyelitis virus entry into the central nervous system following intranasal exposure.
Flexner et al. (1912) studied this question.
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