Population
Rhesus monkeys
Comparison
Intranasal instillation of 1 cc of a 10 per cent… vs Invasion of the central nervous system by other…
Design
Preclinical
Authors
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Does not support changes in human polio care; leaves open peripheral olfactory entry in primate models.
Demonstrates that the poliomyelitis virus causes pathologic changes in the olfactory bulbs only when entering via the olfactory nerves in a rhesus monkey model.
Albert B. Sabin (1937) studied this question.
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