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January 1, 1910JAMAOpen Access

Epidemic Poliomyelitis in Monkeys

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Authors

SFSimon FlexnerRockefeller Foundation

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Implication

Establishes primate model for poliomyelitis transmission; leaves open human applicability and requires validation.

Key Points

  • To investigate the modes of transmission, tissue tropism, and physical properties of the virus causing epidemic poliomyelitis in non-human primates.
  • Inoculated monkeys with infectious material via intracerebral, intraneural (sciatic), intravenous, intraperitoneal, and subcutaneous pathways.
  • Assayed the physical properties of the pathogen using Berkefeld filtration and resistance to glycerination.
  • Demonstrated reliable successive transmission from monkey to monkey most readily through intracerebral inoculation, as well as via peripheral nerves, circulation, peritoneum, and subcutis.
  • Confirmed the causative agent passes through a Berkefeld filter and remains infectious following glycerination.
  • Demonstrated presence of the active virus within spinal cord and brain tissues.

Cite This Study

Simon Flexner (1910) studied this question.

synapsesocial.com/papers/6a968ea13765f84090898609https://doi.org/10.1001/jama.1910.92550270001001p
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Also Consider

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  1. 1EXPERIMENTAL POLIOMYELITIS IN MONKEYS1910 · 61 citations
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  5. 5THE NATURE OF THE VIRUS OF EPIDEMIC POLIOMYELITIS1909 · 26 citations