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February 1, 1931The Journal of Experimental MedicineOpen Access

An Accelerated Febrile Reaction in Monkeys Upon Reinoculation With Poliomyelitis Virus

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Population

Monkeys

Comparison

Reinoculation with poliomyelitis virus vs Primary poliomyelitic infection

Design

Preclinical

Authors

CJC. W. JungeblutInstituto Conmemorativo Gorgas de Estudios de la Salud

Discussion

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Implication

Hypothesizes allergic-type response in recovered primates; leaves open relevance to human poliomyelitis immunity.

Structured PICO

P
Population
Monkeys (recovered from primary poliomyelitic infection or having received parenteral injections of live virus)
I
Intervention
Reinoculation with poliomyelitis virus (intracerebral or subcutaneous injection of killed virus)
C
Comparator
Primary poliomyelitic infection
O
Outcome
Febrile reaction (temperature curve)surrogate

Reinoculation of monkeys with poliomyelitis virus causes an accelerated febrile reaction, suggesting an allergic-type response.

Cite This Study

C. W. Jungeblut (1931) studied this question.

synapsesocial.com/papers/6a95c8e2e844cd4f5c48f870https://doi.org/10.1084/jem.53.2.159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence of Possible Occurrence of Anaphylactic Phenomena in Poliomyelitis Immune Monkeys.1932 · 1 citations
  2. 2OBSERVATIONS ON IMMUNITY OF MONKEYS TO EXPERIMENTAL POLIOMYELITIS1917 · 6 citations
  3. 3EXPERIMENTAL POLIOMYELITIS IN MONKEYS1910 · 61 citations
  4. 4Antibody Response in Monkeys Following Oral Administration of Poliomyelitis Virus1948 · 14 citations
  5. 5HUMORAL ANTIBODIES AND RESISTANCE OF VACCINATED AND CONVALESCENT MONKEYS TO POLIOMYELITIS VIRUS1936 · 18 citations