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September 1, 1935The Journal of Immunology

Tests for Immunity to Acute Anterior Poliomyelitis

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Population

Macacus rhesus monkeys and human serum samples

Design

Other

Authors

JKJohn A. KolmerUniversity of the SciencesARAnna M. RuleUniversity of Rochester

Discussion

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Implication

Standardized neutralization assay enables consistent polio antibody measurement; leaves open validation against contemporary in vitro methods.

Structured PICO

P
Population
Macacus rhesus monkeys and human serum samples
I
Intervention
In vitro antiviral antibody neutralization test
O
Outcome
Neutralization of minimal infective doses of monkey passage virussurrogate

Describes a standardized in vitro neutralization test using Macacus rhesus monkeys to determine susceptibility to poliomyelitis before vaccination.

Limitations

  • Expensive
  • Requires about three weeks to conduct

Cite This Study

Kolmer et al. (1935) studied this question.

synapsesocial.com/papers/6a968ea13765f84090898603https://doi.org/10.4049/jimmunol.29.3.175
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibody in Relation to Immunity in Acute Poliomyelitis1936 · 5 citations
  2. 2Tests for Immunity to Acute Anterior Poliomyelitis1935 · 1 citations
  3. 3Experimental Immunization in Poliomyelitis1927 · 23 citations
  4. 4On the Property of Certain Normal Animal Sera to Neutralize the Virus of Poliomyelitis.1932 · 6 citations
  5. 5A REACTION OF IMMUNITY IN ACUTE POLIOMYELITIS1916 · 3 citations