Why the study?
Can the serum colloidal gold test or complement fixation test substitute for the monkey serum neutralization test for detecting poliomyelitis antibody?
Population
Human and monkey sera
Comparison
Serum colloidal gold test, complement fixation… vs Monkey serum neutralization test
Design
Preclinical
Authors
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Do not substitute colloidal gold or complement fixation tests for neutralization assays; leaves open reliable human polio serology development.
Can the serum colloidal gold test or complement fixation test substitute for the monkey serum neutralization test for detecting poliomyelitis antibody?
The serum colloidal gold test and complement fixation test are not reliable substitutes for the monkey serum neutralization test in detecting poliomyelitis antibodies in humans.
Kolmer et al. (1935) studied this question.
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