Key result
A complement-fixation test using antigens derived from polio-infected suckling mouse brain was positive in 100% of 53 patients with confirmed Type 1 or Type 2 poliovirus infection.
Why the study?
Does a complement-fixation test using unheated antigens derived from suckling mouse brain infected with poliovirus Type 1 or Type 2 improve the diagnosis of acute poliomyelitis?
Population
62 patients clinically diagnosed as cases of acute poliomyelitis in a recent epidemic and 26 controls, age…
Design
Case-control
Follow-up
3-4 weeks
Authors
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Supports serological diagnosis of acute poliomyelitis; hypothesis-generating and requires prospective validation before practice change.
Observational (n=88)
No
Does a complement-fixation test using unheated antigens derived from suckling mouse brain infected with poliovirus Type 1 or Type 2 improve the diagnosis of acute poliomyelitis?
Antigens derived from polio-infected suckling mouse brain provide a highly sensitive and early diagnostic complement-fixation test for acute poliomyelitis.
Golda Selzer (1960) conducted an observational in Acute poliomyelitis (n=88). Complement-fixation test using suckling mouse brain antigens vs. Standard diagnostic methods (virus isolation and neutralizing antibodies) was evaluated on Positive complement-fixation test in patients with confirmed Type 1 or Type 2 poliovirus in stool. A complement-fixation test using antigens derived from polio-infected suckling mouse brain was positive in 100% of 53 patients with confirmed Type 1 or Type 2 poliovirus infection.
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