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August 1, 1955The Journal of Experimental MedicineOpen Access

A Complement Fixation Test for Poliomyelitis

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Why the study?

Can a macroscopic complement fixation test using infected tissue culture fluids accurately diagnose poliomyelitis in clinical patients?

Population

27 individuals with a clinical diagnosis of poliomyelitis

Design

Case_series

Authors

NSNathalie J. SchmidtNorthwestern UniversityELEdwin H. LennetteRockefeller Foundation

Discussion

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Implication

May support serologic diagnosis of poliomyelitis; leaves open prospective validation before clinical adoption.

Structured PICO

Can a macroscopic complement fixation test using infected tissue culture fluids accurately diagnose poliomyelitis in clinical patients?

P
Population
27 individuals with a clinical diagnosis of poliomyelitis
I
Intervention
Macroscopic (tube) complement fixation test using infected tissue culture fluids
O
Outcome
Laboratory diagnosis of poliomyelitis based on complement-fixing antibody titersurrogate

A macroscopic complement fixation test using infected tissue culture fluids can successfully aid in the laboratory diagnosis of poliomyelitis.

Cite This Study

Schmidt et al. (1955) studied this question.

synapsesocial.com/papers/6a8a514c4c30e1095aeca8dehttps://doi.org/10.1084/jem.102.2.133
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS1951 · 59 citations
  2. 2Complement Fixation with Brunhilde and Lansing Poliomyelitis Viruses Propagated in Tissue Culture.1952 · 121 citations
  3. 3COMPLEMENT FIXATION WITH THE THREE TYPES OF POLIOMYELITIS VIRUSES PROPAGATED IN TISSUE CULTURE1231953 · 68 citations
  4. 4COMPLEMENT-FIXATION TEST FOR THE LANSING STRAIN OF POLIOMYELITIS VIRUS121951 · 10 citations
  5. 5The Serological Response of Cotton Rats and Monkeys to Poliomyelitis Virus1951 · 4 citations