Key result
Adaptation of the MEFl poliomyelitis virus to infant mice yielded an increased LD50 titer, enabling the preparation of a suitable antigen for specific and reproducible complement fixation.
Population
Infant mice and adult mice
Comparison
Adaptation of MEFl to infant mice vs Adult mice
Design
Preclinical
Authors
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Enables MEFl antigen preparation for complement fixation assays; leaves open human diagnostic validation.
Adapting the MEFl poliomyelitis virus to infant mice yields higher viral titers suitable for complement fixation tests.
Casals et al. (1950) studied Poliomyelitis. Adaptation of MEFl poliomyelitis virus to infant mice vs. Adult mice was evaluated on Development of LD50 titer and suitability for complement fixation antigen. Adaptation of the MEFl poliomyelitis virus to infant mice yielded an increased LD50 titer, enabling the preparation of a suitable antigen for specific and reproducible complement fixation.
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