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February 1, 1952Experimental Biology and Medicine

Complement Fixation with Brunhilde and Lansing Poliomyelitis Viruses Propagated in Tissue Culture.

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Population

Tissue cultures infected with poliomyelitis viruses, sera of hyperimmunized monkeys, and sera of…

Design

Preclinical

Authors

ASArne SvedmyrNational Institutes of HealthJEJohn F. EndersBoston UniversityAHA. F. HollowayOntario Institute for Cancer Research

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Implication

Should not yet guide clinical serology for poliomyelitis; leaves open validation of concentrated antigens for diagnostic assays.

Structured PICO

P
Population
Tissue cultures infected with poliomyelitis viruses (Lansing and Brunhilde strains), sera of hyperimmunized monkeys, and sera of poliomyelitis patients
I
Intervention
Ultrafiltration for antigen concentration, heating to abolish anticomplementary activity, and the drop method of Fulton and Dumbell for complement fixation tests
O
Outcome
Demonstration of specific antibodies via complement fixationsurrogate

Concentrated antigens from tissue cultures infected with poliomyelitis viruses can be used in complement fixation tests to detect specific antibodies in monkeys and patients.

Cite This Study

Svedmyr et al. (1952) studied this question.

synapsesocial.com/papers/6a7e6d238129fc77b4b29e8dhttps://doi.org/10.3181/00379727-79-19357
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS1951 · 59 citations
  2. 2Complement-Fixation in Experimental and Human Poliomyelitis.1947 · 13 citations
  3. 3A COMPLEMENT FIXATION TEST FOR POLIOMYELITIS1955 · 38 citations
  4. 4COMPLEMENT FIXATION TEST USING THE ANTIGEN PREPARED FROM THE NERVOUS TISSUE OF ADULT MICE INFECTED WITH POLIOMYELITIS VIRUS LANSING TYPE1953
  5. 5COMPLEMENT FIXATION TEST FOR THE LANSING STRAIN OF POLIOMYELITIS VIRUS1952 · 1 citations