Key result
Depot-producing adjuvant accelerates specific complement-fixing antiserum production in monkeys.
Why the study?
Preparation methods for specific complement-fixing antigens from the three poliomyelitis virus prototypes and the role of adjuvant treatment in antiserum production were investigated.
Answers are grounded in this paper and cite their sources.
Specific complement-fixing antigens were prepared from Lansing-, Brunhilde-, and Leon-infected tissues by sedimentation of the viruses in the high speed centrifuge and using the resuspended sediment as antigen. Specific complement fixing antiserums were produced more rapidly in Lansing immunized monkeys when the virus inoculum was incorporated into a depot-producing adjuvant. It appears that the adjuvant treatment as recommended by Salk is needed for production of Brunhilde and Leon complement fixing antiserum.
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Pollard et al. (1952) studied Poliomyelitis. Depot-producing adjuvant was evaluated on Production of specific complement fixing antiserums. Incorporation of a depot-producing adjuvant into the virus inoculum produced specific complement-fixing antiserums more rapidly in monkeys and appears necessary for Brunhilde and Leon strains.
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