Key result
Native poliomyelitis virus type II contains antigenic components present in types I and III.
Population
Animals (including chimpanzees) and humans following infection and immunization with poliomyelitis viruses
Design
Preclinical
Authors
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Antigen sharing in native type II poliovirus is hypothesis-generating; human studies required before clinical implications.
The study demonstrates the presence of shared and type-specific antigenic components among poliomyelitis virus types using complement fixation and absorption techniques.
Hummeler et al. (1958) studied Poliomyelitis. Infection and immunization with poliomyelitis viruses was evaluated on Antibody responses and antigenic components. Absorption techniques demonstrated that native poliomyelitis virus type II contains antigenic components present in types I and III, whereas types I and III absorbed only homologous antibodies.
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