Key result
Concentrated Lansing virus antigen detects complement-fixing antibodies in immunized rats, monkeys, and some humans.
Why the study?
Can complement-fixing antibodies be demonstrated in experimental and human poliomyelitis using concentrated Lansing virus as antigen?
Population
Rats immunized with formalized Lansing virus, convalescent monkeys, and convalescent humans
Comparison
Concentrated Lansing virus from cotton rats used… vs Normal animals (rats)
Design
Preclinical
Authors
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May support complement-fixation assays for poliomyelitis serology; hypothesis-generating and requires prospective human validation before diagnostic use.
Can complement-fixing antibodies be demonstrated in experimental and human poliomyelitis using concentrated Lansing virus as antigen?
The study demonstrates that complement-fixing antibodies can be detected in experimental and human poliomyelitis using concentrated Lansing virus as an antigen.
Loring et al. (1947) studied Poliomyelitis. Concentrated Lansing virus antigen was evaluated on Demonstration of complement-fixing antibodies. Complement-fixing antibodies were successfully demonstrated in immunized rats, convalescent monkeys, and some convalescent humans using concentrated Lansing virus as an antigen.
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