Key result
Certain polioviruses possess complement-fixing and precipitating antigens common to both Type 1 and Type 2 viruses, whereas neutralizing antibodies remain strictly type-specific.
Population
Patients from a recent poliomyelitis epidemic and animals inoculated with isolated viruses
Design
Other
Authors
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May support refined poliovirus serodiagnostics; leaves open effects on immunity assessment in clinical cohorts.
Identifies common complement-fixing and precipitating antigens between Type 1 and Type 2 polioviruses.
Selzer et al. (1961) studied Acute poliomyelitis (n=19). Poliovirus infection was evaluated on Presence of complement-fixing and precipitating antibodies to both Type 1 and Type 2 polioviruses. Certain polioviruses possess complement-fixing and precipitating antigens common to both Type 1 and Type 2 viruses, whereas neutralizing antibodies remain strictly type-specific.
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