Key result
The Eberson Colloidal Gold Test did not distinguish between serums from poliomyelitis convalescent monkeys and normal monkeys, indicating it is not specific for poliomyelitis antibodies.
Why the study?
Is the Eberson Colloidal Gold Test specific for the detection of poliomyelitis antibodies in monkey serum?
Population
poliomyelitis convalescent monkeys and normal monkeys (M. rhesus)
Design
Preclinical
Authors
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Eberson test lacks specificity in monkeys; leaves open its diagnostic utility in humans and requires clinical validation.
Is the Eberson Colloidal Gold Test specific for the detection of poliomyelitis antibodies in monkey serum?
The Eberson Colloidal Gold Test is not specific for poliomyelitis antibodies, as its reactions appear to be driven by non-specific serum ingredients rather than specific antibodies.
Schultz et al. (1934) studied Poliomyelitis. Eberson Colloidal Gold Test vs. Normal monkeys was evaluated on Ability to distinguish between serums from convalescent and normal monkeys. The Eberson Colloidal Gold Test did not distinguish between serums from poliomyelitis convalescent monkeys and normal monkeys, indicating it is not specific for poliomyelitis antibodies.
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