Key result
The ultracentrifugal-intracerebral method detected poliomyelitis in 10 of 11 monkeys compared to 2 of 11 using the intra-abdominal-intranasal method, proving at least 100 times more sensitive.
Why the study?
Does the ultracentrifugal-intracerebral method improve the detection of poliomyelitis virus in monkeys compared to the intra-abdominal-intranasal method?
Does the ultracentrifugal-intracerebral method improve the detection of poliomyelitis virus in monkeys compared to the intra-abdominal-intranasal method?
Absolute Event Rate: 90.9% vs 18.2%
The ultracentrifugal-intracerebral method is significantly more sensitive for detecting poliomyelitis virus in stool specimens than the traditional intra-abdominal-intranasal method.
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May advance experimental virus detection in primate models; leaves open human diagnostic translation.
Joseph L. Melnick (1943) studied Poliomyelitis virus detection (n=11). Ultracentrifugal-intracerebral method vs. Intra-abdominal-intranasal method was evaluated on Development of poliomyelitis in inoculated monkeys. The ultracentrifugal-intracerebral method detected poliomyelitis in 10 of 11 monkeys compared to 2 of 11 using the intra-abdominal-intranasal method, proving at least 100 times more sensitive.
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