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December 1, 1941The Journal of Experimental MedicineOpen Access

Occurrence of Poliomyelitis Virus in Autopsies, Patients, and Contacts

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Key result

Poliomyelitis virus was recovered from 50% of spinal cords and tonsil-adenoid tissue in autopsies, and from the stools of 20% of patients and 5% of contacts.

Population

Autopsies, patients (with and without paralysis), and contacts examined for poliomyelitis virus.

Design

Cross-sectional

Follow-up

Up to 3 months for repeat stools

Authors

JKJohn F. KesselGraduate School Experimental Plant SciencesFMFrederick J. MooreNorthShore University HealthSystemFSFred D. StimpertUniversity of Southern California

Discussion

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Implication

Viral recovery from tissues and stools supports enteric involvement in poliomyelitis; leaves open transmission dynamics and requires prospective confirmation.

Key Points

  • To determine the presence and anatomical distribution of poliomyelitis virus in post-mortem tissues, clinical patients, and household contacts.
  • Tested autopsy tissues (spinal cord, olfactory bulbs, tonsil-adenoid tissue, and colon contents) and stool specimens from paralyzed patients, non-paralyzed patients, and contacts by monkey inoculation.
  • Stratified viral recovery by patient age (<16 vs. ≥16 years), sex, presence of paralysis, and longitudinal follow-up across one to three months.
  • Poliovirus was recovered from 50% of spinal cords, 10% of olfactory bulbs, 50% of tonsil-adenoid tissues, and 26% of colon contents at autopsy, as well as 20% of patient stools and 5% of contact stools.
  • Autopsies with virus-positive spinal cords had concurrent positive tonsil-adenoid tissue or colon contents in 73% of cases.
  • Virus isolation was substantially higher in individuals under 16 years of age for both stool samples (40% of 35 vs. 8% of 38) and spinal cords (71% of 35 vs. 31%), while stool rates were comparable between paralytic (22%) and non-paralytic (19%) cases.

Study Design

Type

Cross-Sectional

Structured PICO

P
Population
Patients, contacts, and autopsies evaluated for the presence of poliomyelitis virus in tissues and stools.
O
Outcome
Recovery of poliomyelitis virus from various tissues (spinal cords, olfactory bulbs, tonsil-adenoid tissue, colon contents) and stools.surrogate

Poliomyelitis virus is frequently recovered from the spinal cords and tonsil-adenoid tissues of fatal cases, and from the stools of patients, particularly those under 16 years of age.

Cite This Study

Kessel et al. (1941) conducted a cross-sectional in Poliomyelitis. Poliomyelitis infection was evaluated on Recovery of poliomyelitis virus. Poliomyelitis virus was recovered from 50% of spinal cords and tonsil-adenoid tissue in autopsies, and from the stools of 20% of patients and 5% of contacts.

synapsesocial.com/papers/6a93259979a63b77ac3300ddhttps://doi.org/10.1084/jem.74.6.601
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RAPID DEVELOPMENT OF CARRIER STATE AND DETECTION OF POLIOMYELITIS VIRUS1945 · 16 citations
  2. 2DETECTION OF THE VIRUS OF POLIOMYELITIS IN THE NOSE AND THROAT AND GASTRO-INTESTINAL TRACT OF HUMAN BEINGS AND MONKEYS1939 · 44 citations
  3. 3PERSISTENCE OF THE VIRUS OF POLIOMYELITIS IN THE NASOPHARYNX1919 · 13 citations
  4. 4Characteristics of Poliomyelitis and Other Enteric Viruses Recovered in Tissue Culture from Healthy American Children.1954 · 164 citations
  5. 5ISOLATION OF POLIOMYELITIS VIRUS FROM THE NASOPHARYNX1935 · 25 citations