Key result
Serum from recovered persons or monkeys contains antibodies that neutralize fatal doses of poliomyelitis virus when incubated for two hours at 37 C.
Serum from individuals or monkeys recovered from acute poliomyelitis contains antibodies capable of neutralizing the virus.
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Indicates neutralizing antibodies in convalescent serum; leaves open whether passive immunization alters poliomyelitis course.
Epidemiologic and experimental investigations have added important facts to our knowledge of immunity in acute poliomyelitis. It has been observed that in widespread epidemics of this disease only a small percentage of the population in the infected area is attacked, and that age susceptibility plays an important rôle; that is, adults usually are immune, and young children are susceptible. Furthermore, as in many other acute infectious diseases, one attack of acute poliomyelitis, whether mild or severe, seems to protect the individual against subsequent infection. These facts have been demonstrated experimentally by many investigators, especially Landsteiner, Flexner, and their associates, and it has been proved that the serum of recovered persons or monkeys contains antibodies which, when the proper experimental conditions are fulfilled, will neutralize fatal doses of poliomyelitis virus. This neutralization occurs when virus and immune serum remain in contact for two hours at 37 C., and for twenty-four hours
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G. Mathers (1916) conducted a review in Acute poliomyelitis. Immune serum from recovered individuals was evaluated on Neutralization of poliomyelitis virus. Serum from recovered persons or monkeys contains antibodies that neutralize fatal doses of poliomyelitis virus when incubated for two hours at 37 C.
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