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April 1, 1932Experimental Biology and Medicine

On the Property of Certain Normal Animal Sera to Neutralize the Virus of Poliomyelitis.

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Key result

Normal serum from 16 immature rhesus monkeys aged 1.5 to 3 years showed no neutralization effect against a 10% poliomyelitis virus suspension (0% neutralization).

Population

16 normal rhesus monkeys ranging in probable age between 1 1/2 and 3 years

Design

Preclinical

Authors

CJC. W. JunoeblutEEEarl T. EngleCollege of Physicians of Philadelphia

Discussion

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Implication

Immature rhesus monkey serum lacks poliomyelitis neutralization; leaves open whether resistance develops via physiological maturation in primates.

Structured PICO

P
Population
16 normal rhesus monkeys aged 1.5 to 3 years tested for the presence of poliomyelitis virucidal substances in their serum.
E
Exposure
Serum tested against 10% poliomyelitis virus suspension (0.6 to 0.8 cc. of serum against 0.6 cc. or 0.4 cc. of virus suspension)
O
Outcome
Neutralization effectsurrogate

Serum from immature normal rhesus monkeys lacks neutralizing power against poliomyelitis virus, supporting the idea that resistance may be a function of physiological maturation.

Cite This Study

Junoeblut et al. (1932) studied Poliomyelitis (n=16). Normal rhesus monkey serum was evaluated on Neutralization effect against a 10% poliomyelitis virus suspension. Normal serum from 16 immature rhesus monkeys aged 1.5 to 3 years showed no neutralization effect against a 10% poliomyelitis virus suspension (0% neutralization).

synapsesocial.com/papers/6a9f8787cd2174b401b20b39https://doi.org/10.3181/00379727-29-6127
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FAILURE TO NEUTRALIZE THE POLIOMYELITIS VIRUS WITH SERA OF ADULT MACACUS RHESUS AND OF YOUNG FEMALE RHESUS TREATED WITH ANTERIOR PITUITARY EXTRACTS1934 · 5 citations
  2. 2AN INVESTIGATION INTO THE SIGNIFICANCE OF HORMONAL FACTORS IN EXPERIMENTAL POLIOMYELITIS1934 · 19 citations
  3. 3Antibody in Relation to Immunity in Acute Poliomyelitis1936 · 5 citations
  4. 4THE NEUTRALIZATION TEST IN POLIOMYELITIS1935 · 26 citations
  5. 5Serum Neutralizing Antibodies to the Infecting Strain of Virus in Poliomyelitis Patients.1948 · 22 citations