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December 1, 1952The Journal of ImmunologyOpen Access

Studies on the Cultivation of Poliomyelitis Viruses in Tissue Culture

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Population

Three prototype strains of poliomyelitis virus in roller cultures of human tissues and rhesus monkey…

Comparison

Roller culture technique for virus propagation vs Suspended cell culture

Design

Preclinical

Authors

FRFrederick C. RobbinsNational Academy of MedicineTWThomas H. WellerLeibniz Institute of European HistoryJEJohn F. EndersBoston University

Discussion

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Implication

May enable efficient poliovirus culture systems; leaves open translation to human vaccine development.

Structured PICO

P
Population
Three prototype strains of poliomyelitis virus (Brunhilde, Lansing and Leon) in roller cultures of human tissues (embryonic skin-muscle and fascia, mature uterus and kidney, mature human testis and prepuce) and rhesus monkey kidney/testicular tissue
I
Intervention
Roller culture technique for virus propagation
C
Comparator
Suspended cell culture
O
Outcome
Viral multiplication/propagationsurrogate

Roller cultures of human and monkey tissues are effective for propagating poliomyelitis viruses, offering advantages over suspended cell cultures.

Cite This Study

Robbins et al. (1952) studied this question.

synapsesocial.com/papers/6a830384687d8bb80798f9f8https://doi.org/10.4049/jimmunol.69.6.673
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cultivation of Poliomyelitis Virus in Tissue Culture III. Synthetic Medium in Roller Tube Cultures.1952 · 10 citations
  2. 2CULTIVATION OF POLIOMYELITIS VIRUS IN TISSUE CULTURE1952 · 13 citations
  3. 3Poliomyelitis Viruses in Tissue Culture. IV. Protein-Free Nutrient Media in Stationary and Roller Tube Cultures.1952 · 41 citations
  4. 4Propagation of Poliomyelitis Virus in Cultures of Monkey and Human Testicular Tissues.1951 · 34 citations
  5. 5STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES1952 · 167 citations