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November 1, 1955The Journal of ImmunologyOpen Access

An Evaluation of the Roller-Tube Tissue Culture for the Isolation of Poliomyelitis Viruses from Feces

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Why the study?

Does the roller-tube tissue culture technique effectively isolate poliomyelitis viruses from feces of patients with paralytic and nonparalytic poliomyelitis?

Population

241 fecal specimens

Comparison

Roller-tube tissue culture technique employing… vs Alternate technique or modified procedures

Design

Other

Authors

SKSidney KibrickBoston UniversityJEJohn F. EndersBoston UniversityFRFrederick C. RobbinsNational Academy of Medicine

Discussion

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Implication

May support diagnostic virus isolation in suspected poliomyelitis; leaves open prospective validation before clinical adoption.

Structured PICO

Does the roller-tube tissue culture technique effectively isolate poliomyelitis viruses from feces of patients with paralytic and nonparalytic poliomyelitis?

P
Population
241 fecal specimens (216 single specimens from patients being examined for poliomyelitis viruses, plus 25 previously positive specimens)
I
Intervention
Roller-tube tissue culture technique employing mostly human tissues
C
Comparator
Alternate technique or modified procedures
O
Outcome
Isolation and recovery of poliomyelitis virusessurrogate

The roller-tube tissue culture technique is highly sensitive for isolating poliomyelitis viruses from feces, particularly in paralytic cases.

Cite This Study

Kibrick et al. (1955) studied this question.

synapsesocial.com/papers/6a71b0e9f44fa9f079df6da0https://doi.org/10.4049/jimmunol.75.5.391
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Methods for Recovering Poliomyelitis Viruses from Human Sources.1954 · 14 citations
  2. 2Studies on the Cultivation of Poliomyelitis Viruses in Tissue Culture1952 · 50 citations
  3. 3Cultivation of Poliomyelitis Virus in Tissue Culture III. Synthetic Medium in Roller Tube Cultures.1952 · 10 citations
  4. 4TISSUE CULTURE DIAGNOSIS OF POLIOMYELITIS AND ASEPTIC MENINGITIS1955 · 19 citations
  5. 5Poliomyelitis Viruses in Tissue Culture. IV. Protein-Free Nutrient Media in Stationary and Roller Tube Cultures.1952 · 41 citations