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May 1, 1954Experimental Biology and Medicine

Comparison of Methods for Recovering Poliomyelitis Viruses from Human Sources.

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Key result

Monkey kidney epithelial cell cultures were superior to HeLa or testicular cultures for the primary isolation of poliomyelitis virus from oropharyngeal specimens.

Why the study?

Are monkey kidney epithelial cell cultures superior to other tissue cultures or live monkeys for recovering poliomyelitis virus from human specimens?

Population

104 fecal and oropharyngeal specimens obtained directly from human sources

Comparison

Monkey kidney epithelial cell cultures and… vs HeLa cultures, testicular cultures, and live…

Design

Preclinical

Authors

HWHerbert A. WennerUniversitäts FrauenklinikCMCharles A. MillerWyoming State Department of Health

Discussion

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Implication

May advance lab isolation techniques; leaves open translation to modern clinical diagnostics.

Structured PICO

Are monkey kidney epithelial cell cultures superior to other tissue cultures or live monkeys for recovering poliomyelitis virus from human specimens?

P
Population
104 fecal and oropharyngeal specimens obtained directly from human sources to compare methods for recovering poliomyelitis viruses.
E
Exposure
Monkey kidney epithelial cell cultures and tissue culture methods
C
Comparator
HeLa cultures, testicular cultures, and live monkeys
O
Outcome
Poliomyelitis virus recovery/isolation ratessurrogate

Monkey kidney epithelial cell cultures are superior for isolating poliovirus from oropharyngeal specimens compared to HeLa or testicular cultures.

Cite This Study

Wenner et al. (1954) studied Poliomyelitis (n=104). Monkey kidney epithelial cell cultures vs. HeLa or testicular cultures, and monkeys was evaluated on Virus recovery rates. Monkey kidney epithelial cell cultures were superior to HeLa or testicular cultures for the primary isolation of poliomyelitis virus from oropharyngeal specimens.

synapsesocial.com/papers/6a92fb8c7dc82e97087f4f5ehttps://doi.org/10.3181/00379727-86-20997
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Evaluation of the Roller-Tube Tissue Culture for the Isolation of Poliomyelitis Viruses from Feces1955 · 26 citations
  2. 2STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES1952 · 168 citations
  3. 3Characteristics of Poliomyelitis and Other Enteric Viruses Recovered in Tissue Culture from Healthy American Children.1954 · 164 citations
  4. 4Propagation of Poliomyelitis Virus in Cultures of Monkey and Human Testicular Tissues.1951 · 34 citations
  5. 5CULTIVATION OF POLIOMYELITIS VIRUS IN TISSUE CULTURE1952 · 13 citations