Key result
The Lansing strain of poliomyelitis virus successfully multiplied in human embryonic skin and muscle tissues, but showed evidence of multiplication in only 2 of 13 human placental tissue cultures.
Population
Human embryonic tissue cultures and human placental tissue cultures; mice and rhesus monkeys for identity…
Design
Preclinical
Authors
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Supports poliovirus propagation in non-neural tissues; leaves open placental tropism mechanisms for further study.
The Lansing strain of poliomyelitis virus can be propagated in human embryonic non-nervous tissues, particularly skin and muscle, but poorly in placental tissues.
Milzer et al. (1950) studied Poliomyelitis. Cultivation of Poliomyelitis Virus (Lansing Strain) was evaluated on Virus multiplication in tissue cultures. The Lansing strain of poliomyelitis virus successfully multiplied in human embryonic skin and muscle tissues, but showed evidence of multiplication in only 2 of 13 human placental tissue cultures.
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