Key result
The Lansing strain of poliomyelitis virus survived and propagated in human embryonic kidney cultures for over 100 days, achieving virus titers of more than 10^-3.0.
Population
Maitland-type cultures of human tissue derived from embryonic brain and cord, kidney, and tonsillar tissue
Design
Preclinical
Follow-up
over 100 days
Authors
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Enables sustained poliovirus studies in human kidney cultures; leaves open extension to other tissues or clinical models.
The study demonstrates the successful prolonged cultivation of the Lansing strain of poliomyelitis virus in human embryonic tissues using a synthetic nutrient medium.
Franklin et al. (1953) studied Poliomyelitis virus propagation. Cultivation in synthetic nutrient medium was evaluated on Virus survival and propagation time. The Lansing strain of poliomyelitis virus survived and propagated in human embryonic kidney cultures for over 100 days, achieving virus titers of more than 10^-3.0.
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