October 29, 1998Open Access
Ver artículo completoEffect of Bradykinin-Receptor Blockade on the Response to Angiotensin-Converting–Enzyme Inhibitor in Normotensive and Hypertensive Subjects
PICO estructurado
Does bradykinin-receptor blockade alter the short-term effects of ACE inhibition on blood pressure and the renin-angiotensin system in normotensive and hypertensive subjects?
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Población
Normotensive and hypertensive persons
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Intervención
Bradykinin-receptor blockade combined with Angiotensin-Converting-Enzyme (ACE) inhibitor
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Resultado
Blood pressure and renin-angiotensin system responsesurrogate
Bradykinin plays a mechanistic role in the short-term blood pressure-lowering and renin-angiotensin system effects of ACE inhibitors.
Resumen
These data confirm that bradykinin contributes to the short-term effects of ACE inhibition on blood pressure in normotensive and hypertensive persons and suggest that bradykinin also contributes to the short-term effects of ACE inhibition on the renin-angiotensin system.