Does bradykinin-receptor blockade alter the short-term effects of ACE inhibition on blood pressure and the renin-angiotensin system in normotensive and hypertensive subjects?
Bradykinin plays a mechanistic role in the short-term blood pressure-lowering and renin-angiotensin system effects of ACE inhibitors.
These data confirm that bradykinin contributes to the short-term effects of ACE inhibition on blood pressure in normotensive and hypertensive persons and suggest that bradykinin also contributes to the short-term effects of ACE inhibition on the renin-angiotensin system.
Gainer et al. (1998) studied this question.