Evidence for a Central Mechanism in Angiotensin Induced Hypertension.

SummaryAngiotensin II appears to produce an increase in blood pressure by 2 mechanisms: 1. A direct peripheral action on the vascular smooth musculature producing a marked increase in peripheral resistance, which is not blocked by piperoxan. 2. A central hypertensive effect, probably due to stimulation of central sympathetic structures and evoking peripheral sympathetic discharges, which are blocked by administration of a sympatholytic agent into the peripheral circulation.