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Investigates the central role of angiotensin in hypertension, suggesting key pathways for treatment.
SummaryAngiotensin II appears to produce an increase in blood pressure by 2 mechanisms: 1. A direct peripheral action on the vascular smooth musculature producing a marked increase in peripheral resistance, which is not blocked by piperoxan. 2. A central hypertensive effect, probably due to stimulation of central sympathetic structures and evoking peripheral sympathetic discharges, which are blocked by administration of a sympatholytic agent into the peripheral circulation.
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Bickerton et al. (1961) studied this question.
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