5/6 renal ablation in rats led to significantly higher mean systolic blood pressure compared to sham ablation (138 vs. 117 mmHg, P<0.01), which strongly correlated with glomerular injury (r=0.88).
Does systemic hypertension correlate with glomerular injury in the rat remnant kidney model?
Continuous telemetric monitoring reveals a strong correlation between systemic hypertension and glomerular injury in the rat remnant kidney model.
Absolute Event Rate: 138% vs 117%
p-value: p=< 0.01
The pathogenesis of glomerular injury in the remnant kidney (RK) model remains controversial. Increased glomerular transmission of systemic hypertension has been postulated to be an important pathogenic mechanism, but the precise relationship between systemic pressures and glomerular injury has not been defined because of the limitations of the tail-cuff method. Systolic blood pressure (BP) was continuously recorded radiotelemetrically at 10-min intervals for 6 wk in rats after approximately 5/6 renal ablation (n = 16) or sham ablation (n = 7). Overall mean systolic BP in RK rats was significantly higher than sham (138 +/- 3.3 vs. 117 +/- 1.3 mmHg, P 140 mmHg. These data strongly suggest that transmission of systemic hypertension to the renal microvasculature plays a predominant role in the pathogenesis of glomerular injury in the RK model and also support the potential usefulness of the radiotelemetric technique to investigate hypertensive target organ injury.
Bidani et al. (Wed,) conducted a other in Glomerular injury in remnant kidney model (n=23). 5/6 renal ablation vs. Sham ablation was evaluated on Overall mean systolic blood pressure (p=< 0.01). 5/6 renal ablation in rats led to significantly higher mean systolic blood pressure compared to sham ablation (138 vs. 117 mmHg, P<0.01), which strongly correlated with glomerular injury (r=0.88).
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