Key result
5/6 renal ablation in rats led to significantly higher mean systolic blood pressure compared to sham ablation (138 vs. 117 mmHg, P<0.01), which strongly correlated with glomerular injury (r=0.88).
Why the study?
Does systemic hypertension correlate with glomerular injury in the rat remnant kidney model?
Population
Rats undergoing approximately 5/6 renal ablation (n=16) or sham ablation (n=7)
Comparison
Approximately 5/6 renal ablation with continuous… vs Sham ablation
Design
Preclinical
Follow-up
6 weeks
Authors
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Strengthens remnant kidney model for hypertensive glomerular injury; leaves open translation to human CKD.
Does systemic hypertension correlate with glomerular injury in the rat remnant kidney model?
Absolute Event Rate: 138% vs 117%
p-value: p=< 0.01
Continuous telemetric monitoring reveals a strong correlation between systemic hypertension and glomerular injury in the rat remnant kidney model.
Bidani et al. (1993) studied Glomerular injury in remnant kidney model (n=23). 5/6 renal ablation vs. Sham ablation was evaluated on Overall mean systolic blood pressure (p=< 0.01). 5/6 renal ablation in rats led to significantly higher mean systolic blood pressure compared to sham ablation (138 vs. 117 mmHg, P<0.01), which strongly correlated with glomerular injury (r=0.88).
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