Why the study?
Does enalapril or felodipine improve functional and structural damage in a rat remnant kidney model of chronic renal failure?
Population
Female Sprague-Dawley rats subjected to surgical removal of the right kidney and segmental infarction of…
Comparison
Enalapril or felodipine administered from 1 week… vs Untreated rats with the same surgical remnant…
Design
Preclinical, Blinded histological scoring for glomerulosclerosis
Follow-up
6 weeks post-nephrectomy
Authors
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Suggests BP-independent renoprotection by ACE inhibition in experimental CKD; hypothesis-generating and leaves open clinical translation.
Does enalapril or felodipine improve functional and structural damage in a rat remnant kidney model of chronic renal failure?
In a rat model of chronic renal failure, ACE inhibition with enalapril preserved renal function and structure, whereas calcium channel blockade with felodipine did not, despite comparable blood pressure reduction.
Jackson et al. (1986) studied this question.
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