Population
22 Wistar rats evaluated 60 days after removal of the clipped kidney in the Goldblatt hypertension model.
Comparison
Persistent hypertension (HBP group) vs Normotensive rats (NBP group)
Design
Preclinical
Follow-up
60 days after removal of the clipped kidney
Authors
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Supports glomerular pressure elevation in renovascular rat models; hypothesis-generating for human hypertension mechanisms, with no clinical implications yet.
In a rat model of persistent renovascular hypertension, elevated arterial pressure is maintained by adaptations in the unclipped kidney, including increased glomerular capillary pressure and a decreased ultrafiltration coefficient.
Herrera-Acosta et al. (1983) studied this question.
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