Why the study?
Does the contralateral kidney in two-kidney, one clip renal vascular hypertensive rats maintain autoregulation of renal blood flow and GFR during acute blood pressure reduction compared to normal rats?
Population
Two-kidney, one clip renal vascular hypertensive rats (n=11) and normal rats (n=7)
Comparison
Acute reduction of renal arterial blood pressure vs Normal rats undergoing acute reduction of renal…
Design
Preclinical
Authors
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May contribute to hypertension maintenance in Goldblatt rats; leaves open relevance to human renovascular hypertension.
Does the contralateral kidney in two-kidney, one clip renal vascular hypertensive rats maintain autoregulation of renal blood flow and GFR during acute blood pressure reduction compared to normal rats?
The contralateral kidney in Goldblatt hypertensive rats exhibits severely impaired autoregulation of renal blood flow and GFR during acute blood pressure reduction, potentially contributing to the maintenance of hypertension.
Ploth et al. (1981) studied this question.
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