Inter-Relationship between Autoregulation of Glomerular Filtration Rate, Tubuloglomerular Feedback and Juxtaglomerular Renin Activity in Normotensive and Hypertensive Rats

View Full Paper

Ask AI

Bookmark

Population

Normotensive (control) rats and Goldblatt hypertensive rats

Comparison

Reduction of renal perfusion pressure and acute… vs Control rats and contralateral kidneys of…

Design

Preclinical

Authors

Discussion

Supports TGF in renal autoregulation in this animal model; leaves open relevance to human renovascular disease.

Population

Normotensive (control) rats and Goldblatt hypertensive rats

Intervention

Reduction of renal perfusion pressure (from 133 mmHg to 117 mmHg) and acute removal of constricting clip in Goldblatt rats

Comparator

Control rats and contralateral kidneys of Goldblatt hypertensive rats

Outcome

Kidney glomerular filtration rate (GFR) and nephron GFR in distal and proximal tubulessurrogate

Tubuloglomerular feedback, possibly mediated by the renin-angiotensin system, participates in establishing renal autoregulation.

Schnermann et al. (1976) studied this question.

View Full Paper

Ask AI

Bookmark